Inherited cardiomyopathies — diseases of the heart muscle, which cause the heart to have a harder time pumping blood to the rest of the body — are the leading cause of heart failure in young adults. Desmin-related cardiomyopathy (DRM) is one such familial disease that affects approximately 1 in 2,000 individuals worldwide. No disease-specific therapies exist for DRM, with patients receiving only generic heart failure medicines.
DRM is caused by mutations in the genes for desmin — a muscle-specific intermediate filament protein — or its protein-folding chaperone, αB-Crystallin (CRYAB). These mutations are thought to cause desmin to misfold and form toxic clumps inside heart muscle cells.















































