Philip A. Ludbrook, MD, MRCP (UK), FRACP

Philip A. Ludbrook, MD, MRCP (UK), FRACP

Professor Emeritus of Medicine and Psychiatry

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Research Profile

Education

  • Premedical Education: Prince Alfred College, Adelaide, South Australia (1957)
  • MBBS, MBChB: University of Adelaide School of Medicine, Adelaide, South Australia (1963)
  • Rotating Internship: Queen Elizabeth Hospital, South Australia (1965)
  • Resident: Internal Medicine and Cardiology, Royal Adelaide Hospital (1967)
  • Post-Graduate Education: Department of Pathology, Department of Internal Medicine, and Cardiovascular Division, University of Adelaide School of Medicine, South Australia (1970)
  • Post-Graduate Education: Queen Elizabeth Hospital and Royal Adelaide Hospital (1970)
  • Clinical Cardiology: Royal Post-Graduate Medical School, University of London (1971)
  • Australian Heart Foundation Research Fellow: Cardiovascular Division, UCSD, San Diego, CA (1973)
  • Overseas Clinical Research Fellow of the Australian National Heart Foundation: Department of Medicine, Cardiovascular Division, UCSD, San Diego, CA (1973)

Recognition

  • Best Doctor in St. Louis, Multiple Years
  • Best Doctor in America, Multiple Years
  • Award for Excellence in Human Research Protection, 2006
  • Human Research Protection Award Recipient, 2005
  • The Dr. Neville Grant Award For Clinical Excellence, 2003
  • Barnes-Jewish Hospital Caring Spirit Award, 1999

Clinical Interests

Adult Congenital Heart Disease, including diagnosis and management of advanced complex congenital heart disease refractory to therapy, diagnostic cardiac catheterization for coronary artery disease, valvular heart disease, cardiomyopathy, congenital heart disease, pericardial disease, pulmonary hypertension, and exercise-induced hemodynamic abnormalities.

Research Interests

Diastolic and systolic left and right ventricular mechanics, and ventricular interaction. Characterization of early diastolic relaxation and ventricular filling. Pharmacologic modifiers of diastolic function. Pathologic modifiers of diastolic dysfunction (ischemia, diabetes, hypertension, abnormal loading conditions). Role of tissue plasminogen activator, streptokinase, role of complementary drugs. Cardiac Imaging:  angiography, echocardiography, magnetic resonance imaging, CT, PET.

Congenital heart disease: Diagnostic imaging in Adults with Congenital Heart Disease; management of patients with late-stage cavo-pulmonary shunts; hemodynamic pathophysiology and clinical sequelae of Fontan and Glenn shunts; psycho/social issues in Adults with Congenital Heart Disease; pregnancy in Adults with Congenital Heart Disease; arrhythmias in Adults with Congenital Heart Disease

Ethics, law and federal regulations of human participant research:

Research ethics and its history; Nazi medical experimentation during the Holocaust; Investigative Drug And Device research; placebo and sham research; equipoise and randomization in research; medical malpractice in biomedical research; modification or waiver of informed consent; teaching medical and research ethics; informed consent in and diminished autonomy; high risk research in children; confliction priorities of ethics and the federal regulations and law; innovative medical procedures.