Zhen Guo, PhD

Instructor in Medicine


  • MS: Hubei University of Chinese Medicine, Wuhan China (2012)
  • MD: School of Pharmacy, Nanchang University, Jiangxi China (2015)
  • PhD: Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen Univeristy, Guangzhou China (2018)


  • 2nd Scholarship, Hubei University of Chinese Medicine, 2009
  • Outstanding graduates of Nanchang University, 2015
  • 3rdScholarship, Sun Yat-sen University, 2017
  • Bidi Scholarship, Sun Yat-sen University, 2018
  • Kern Lipid Conference Early Career Investigator Award, 2022
  • Kern Lipid Conference Roger Davis Award for Transitional Faculty (runner up), 2023

Research Interests

Lipid metabolism, epigenetics and heart disease

  • Omics approaches explore the transcriptional signature of the human diseased heart
  • The role and mechanism of Apolipoprotein M/A1 in heart failure and doxorubicin cardiomyopathy
  • Lipophagy and muscle catabolism under stress
  • Intermittent fasting and doxorubicin cardiotoxicity
  • The role and mechanism of secreted proteins (sFRP1 and Dkk1) in doxorubicin-induced cardiotoxicity
  • The role of vascular oxidative stress in type II diabetes and abdominal aortic aneurysm
  • The role and mechanism of histone demethylase (JMJD3 and JMJD6) and deacetylase (SIRT1) in pathological cardiac hypertrophy