Mohamed Ameen Mohamed Ismahil, PhD
Assistant Professor of Medicine
- Phone: 314-362-1291
- Bachelor’s in Zoology: Baharathidasan University, Tiruchirappalli, Tamilnadu, India (1994)
- Master’s in Biochemistry: Baharathidasan University, Tiruchirappalli, Tamilnadu, India (1997)
- PhD Biochemistry: Hamdard University, New Delhi, India (2004)
Heart failure is characterized by chronic inflammation and increased myocardial infiltration of activated immune cells including monocytes, macrophages, dendritic cells and T-cells. My research efforts focus on the elucidation of innate (macrophages and dendritic cell) and adaptive immune responses during chronic heart failure and the role of these immune cells in mediating pathological left-ventricular remodeling. My current research specifically focuses on the role of splenic macrophage subsets (inner and outer marginal zone and red pulp macrophages) and its function in post infarcted left ventricular remodeling, and delineate the role of plasmacytoid dendritic cells (pDCs) and its pathological role in cardiac remodeling in HF. As an extension, I am interested in identifying and developing novel therapeutic strategies to reverse pathological changes in immune cell for their bench-to-bed transition.