Abhinav Diwan, MD, FACC, FAHA
Associate Professor of Medicine
- M.B.B.S. (MD): All India Institute of Medical Sciences, New Delhi, India (1997)
- Internship, Internal Medicine: Baylor College of Medicine, Houston, TX (1998)
- Residency, Internal Medicine: Baylor College of Medicine, Houston, TX (2001)
- Fellowship, Cardiology: Baylor College of Medicine, Houston, TX (2004)
- Cardiovascular Disease
Melvin Marcus Young Investigator Award in Cardiovascular Science from American Heart Association
Finalist, Arnold and Louis Katz Basic Science Research Prize from American Heart Association
Jeremiah Stamler Distinguished Young Investigator Award in the junior faculty basic science category in the Northwestern Cardiovascular Young Investigator’s Forum.
Finalist, Jay N. Cohn Young Investigator Award in Basic Cardiovascular Sciences, Heart Failure Society of America.
My research focuses on the role of lysosomes in cardiac myocyte cell death in response to myocardial ischemia-reperfusion injury. In particular, my lab is studying autophagosome processing and transcriptional replenishment of autophagy-lysosome machinery as determinants of beneficial autophagy in cardiac myocytes under stress. Impaired autophagosome-lysosome fusion and accumulation of autophagic vacuoles is the hallmark of Danon disease, a condition characterized by hypertrophic cardiomyopathy, and caused by mutations in LAMP2 gene, which leads to loss of functional LAMP2 protein. The lab is characterizing the role of LAMP2 in autophagosome-lysosome fusion and cardiomyocyte viability. Our objective is to develop strategies to enhance beneficial autophagy signaling to promote cardiac myocyte function and survival under stress.