Heart Failure

  • ATHENA: Effects of ziltivekimab versus placebo on heart failure symptoms and physical function in patients with heart failure with mildly reduced or preserved ejection fraction and systemic inflammation. Justin Vader, MD. Novo Nordisk.
    CURRENTLY ENROLLING
  • Cycle-1: A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study to Assess the Safety and Effectiveness of Tovinotrine in Patients with Chronic Heart Failure With Reduced Ejection Fraction. Sumanth Prabhu, MD. Cardurion Pharmaceuticals. CURRENTLY ENROLLING
  • Cycle-2: A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study to Assess the Safety and Effectiveness of Tovinotrine in Patients with Chronic Heart Failure With Preserved Ejection Fraction. Sumanth Prabhu, MD. Cardurion Pharmaceuticals.
    CURRENTLY ENROLLING
  • COMET: A multi-center, double-blind, randomized blacebo-controlled trial to assess efficacy and safety of omecamtiv mecarbil in patients with symptomatic heart failure with severely reduced ejection fraction. Justin Vader, MD. Cytokinetics, Inc.
    CURRENTLY ENROLLING
  • CORCINCH:  Randomized clinical evaluation of the AccuCinch Ventricular Restoration System in patients who present with symptomatic heart failure with reduced ejection fraction.  Justin Vader, MD. Ancora Heart.
  • DCM Consortium:  Identification of the genetic causes of dilated cardiomyopathy and related conditions. Gregory Ewald, MD. Ohio State University.
  • Garden-TIMI:  Investigating symptoms, function, health-related quality of life and safety with repeated subcutaneous administration of ponsegromab v placebo in adult participants with heart failure. Justin Hartupee, MD. Pfizer Inc. (pending)
  • MUSIC-HF:  Phase I/II trial of the safety and efficacy of SRD-001 in subjects with heart failure with reduced ejection fraction. Gregory Ewald, MD. Sardocor Corp.
  • PROACTIVE- HF-2 Trial-A Prospective, Multi-Center, Open Label, Randomized Control Clinical Trial Evaluating the Safety and Efficacy of the Cordella™ Pulmonary Artery Sensor System in New York Heart Association (NYHA) Class II – III Heart Failure Patients. Justin Vader, MD. Endotronix.
    CURRENTLY ENROLLING
  • REBIRTH:  Randomized evaluation of bromocriptine in myocardial recovery therapy for peripartum cardiomyopathy. Gregory Ewald, MD. University of Pittsburgh.
  • REHAB-pEF  Physical Rehabilitation for older patients with acute heart failure with preserved ejection fraction. Justin Vader, MD. National Institute of Aging.
  • RESONANCE: Registry of the natural history of recurrent pericarditis in pediatric and adult patients. Amanda Verma, MD. Kiniksa Pharmaceuticals.
  • SALUBRIS:  A study to assess the safety and tolerability of JK07 in subjects with heart failure with preserved ejection fraction. Nancy Sweitzer, MD. Salubris Biotherapeutics, Inc.
  • SHORE:  Surveillance Heartcare (allomap and allosure) outcomes registry. Gregory Ewald, MD. CareDx.
  • TCBR:  Translational cardiovascular biobank and repository. Gregory Ewald, MD.  Washington University.