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C. William Balke, MD

Professor of Medicine

Phone314-652-4100

Additional Titles

  • Chief of Cardiology, St. Louis VA Health Care System

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Education

  • B.S. Biology: Haverford College, Haverford, PA (1975)
  • B.A. Philosophy & Comparative Literature: University of Pennsylvania, Philadelphia, PA (1977)
  • M.D.: Temple University School of Medicine, Philadelphia, PA (1981)
  • Internship: Osler Medical Service, Johns Hopkins Hospital, Baltimore, MD (1982)
  • Residency: Osler Medical Service, Johns Hopkins Hospital, Baltimore, MD (1984)
  • Clinical and Research Fellow, Cardiovascular Division: Brigham and Women's Hospital, Boston, MA (1985)
  • Assistant Chief of Service: Osler Medical Service, Johns Hopkins Hospital, Baltimore, MD (1986)
  • Clinical and Research Fellow, Cardiovascular Division: Brigham and Women's Hospital, Boston, MA (1988)
  • Visiting Clinical and Research Electrophysiology Fellow, Cardiology Section: Hospital of the University of Pennsylvania, Philadelphia, PA (1988)
  • Post-doctoral Research Fellow: Department of Physiology, University of Maryland School of Medicine (1991)

Board Certifications

  • Cardiovascular Disease

Recognition

1990-1991

Samuel M. Jacobson, MD Fellow of the AHA-Maryland Affiliate

1990

Clinician-Scientist Award, American Heart Association

1990-1995

Physician-Scientist Award, National Institutes of Health

1998-2002

Established Investigator Award, American Heart Association

2001

Fellow, Council on Basic Cardiovascular Sciences, American Heart Association
Fellow, American Heart Association (FAHA)

2004

Fellow, American College of Physicians (FACP)

2010-2012: Member, NIH College of CSR Reviewers

Research Interests

My research interests focus on the role of individual ions (especially calcium) as second messengers in the regulation of a variety of cellular processes relevant to cardiovascular function. Active research projects include: (1) the investigation of the cellular and molecular mechanisms of excitation-contraction-relaxation coupling in normal cardiac atrial and ventricular cells and multicellular preparations (i.e. trabeculae) obtained from animal and human hearts, (2) the study of the cellular mechanisms responsible for the systolic and diastolic abnormalities of contraction characteristic of hypertensive heart disease (cardiac hypertrophy and heart failure) in single cells and trabeculae obtained from animal models of contractile dysfunction and failing human hearts, (3) the investigation of the biophysical properties and physiological function of a newly described sodium channel in cardiac muscle. Experimental techniques include: (1) the patch clamp technique (whole-cell & single channel variations), (2) epifluorescence microscopy with ion-selective fluorescent indicators, (3) flash photolysis of “caged” compounds, (4) laser scanning confocal microscopy (single & two photon), and (5) mathematical modeling.

Publications

View publications on PubMed.gov