Peter A. Crawford, MD, PhD

crawford peterAssistant Professor, Cardiovascular Division, Department of Medicine; Department of Genetics; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO

Contact Information: 
660 S. Euclid Ave., Campus Box 8086 
St. Louis, MO 63110
Lab and office: 823 CSRB-NT 
Office: 314-747-3009 
Lab: 314-747-3187 
Fax: 314-362-0186 
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Website: http://crawfordlab.wustl.edu

Education and Training:
1999 M.D., Washington University School of Medicine, St. Louis, MO
1999 Ph.D., Neuroscience Program, Washington University School of Medicine, St. Louis, MO
1991 B.S. Zoology, Duke University, Durham, NC 
2005-2007 Instructor of Medicine, Departments of Medicine, Division of Cardiology, and Molecular Biology and Pharmacology, Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 
2003-2006 Postdoctoral Fellow (Advisor: Dr. Jeffrey I. Gordon), 
Department of Medicine, Division of Cardiology; and Center for Genome Sciences, Washington University, St. Louis, MO 
1993-1997 Ph.D. Thesis (Advisor: Dr. Jeffrey Milbrandt), Departments of Pathology and Medicine, Washington University, St. Louis, “The roles of nuclear receptors in the urogenital ridge”

Honors and Awards:
Knowlton Incentive for Excellence Award, Barnes-Jewish Hospital Foundation, 2001 
Alpha Omega Alpha, Washington University School of Medicine, 1999 
Washington University Internal Medicine Club Award, 1999 
Spencer T. and Ann M. Olin Medical Scientist Fellow, Washington University School of Medicine, 1997 
Graduation with Distinction, Duke University, 1991 
Golden Key National Honor Society, Duke University, 1988

Clinical Expertise: 
Adult inpatient general cardiology

Research Interests:
Obesity and cardiovascular disease are among the leading causes of morbidity and mortality worldwide. Our research focuses on the interplay between intermediary metabolism and these disease processes. Derangements in the processing of carbohydrates, fats, and amino acids are central drivers of pathogenesis, but the roles of another metabolic fuel class, ketone bodies, are less well understood. We use novel genetic mouse models with engineered deficiencies in ketone body metabolism to study the metabolic shifts that occur in response to obesity, cardiovascular disease, and dynamic environmental challenges. From these models, we have developed new perspectives of how nutrient metabolism adapts in obesity and cardiomyopathy, and how these adaptations ultimately prove deleterious. We leverage recent advances in NMR and mass spectrometry technologies to study metabolism on a systems level, and we also employ established techniques in molecular cell biology and biochemistry to reveal phenotypic shifts at the cellular level. In addition to our mouse studies, we are also performing studies in humans to learn how alterations of ketone metabolism may serve as a diagnostic biomarker and therapeutic target for obesity-related disease, cardiac dysfunction, and metabolic maladaptations that can occur in the neonatal period.

Publications:  pubmed logo