Washington University - Cardiovascular Division

Samuel A. Wickline, M.D.

Professor of Medicine, Physics, Biomedical Engineering, Cell Biology and Physiology; Director, Washington University Consortium for Translational Research in Advanced Imaging and Nanomedicine (C-TRAIN); Director, Siteman Center For Cancer Nanotechnology Excellence; Executive Faculty, Institute of Biological and Medical Engineering; Co-Director of Cardiovascular Engineering Graduate Training Program, Biomedical Engineering Department, Washington University School of Medicine, St. Louis, MO

Contact Information:
Office: 4320 Forest Park; St. Louis, MO 63108
Telephone: 314-454-8635
Email: saw@wuphys.wustl.edu
Website: http://ctrain.wustl.edu/

Education and Training:
Undergraduate:
Pomona College; Claremont, California (1970-74) BA: Philosophy

Graduate:
University of Hawaii School of Medicine; Honolulu, Hawaii (1976-1980)

Academic Positions/Employment:
1974-1976: Research Associate, Cardiovascular Research Laboratory, Queens Hospital and John A. Burns School of Medicine; Honolulu, Hawaii
1980-83: Internship and Residency in Internal Medicine: Barnes Hospital; Washington University School of Medicine; St. Louis, MO
1983-87: Clinical and Research Fellowships in Cardiology: Washington University School of Medicine; Barnes Hospital; St. Louis, MO (Research Fellow 1983-85)
1987: Assistant Professor of Medicine, Washington University School of Medicine, Barnes Hospital; St. Louis, MO
1988: Clinician-Scientist of the American Heart Association
1990: Assistant Professor of Physics, Washington University, Department of Physics; St. Louis, MO
1992: Attending Cardiologist and Director of Echocardiography, The Jewish Hospital at Washington University; St. Louis, MO
1993: Established Investigator of the American Heart Association
1993: Associate Professor of Medicine, Washington University School of Medicine
1993-97: Chief of Cardiology, Jewish Hospital, Washington University School of Medicine
1994: Associate Professor of Physics, Washington University , Department of Physics; St. Louis, MO
1996: Co-Director of Cardiovascular Division, Washington University School of Medicine and Barnes-Jewish Hospital
1996: Co-Director of Washington University Cardiovascular Engineering Program and Member of Executive Council, Institute of Biological and Medical Engineering, Washington University , School of Engineering and Applied Sciences
1997: Professor of Medicine, Washington University School of Medicine
1997: Professor of Physics and of Biomedical Engineering, Washington University School of Medicine
2003: Professor of Cell Biology and Physiology, Division of Biology and Biomedical Sciences, Washington University School of Medicine

Honors and Awards:
B.A. degree: Cum Laude; Pomona College
Lange Award for Outstanding Student sophomore, junior, and senior years; John A. Burns School of Medicine; Honolulu, Hawaii
First place awardee: University of Hawaii Biomedical Science Symposium (1977) for presentation of "Vectorcardiographic Infarct Sizing in Baboons"
Alpha Omega Alpha, 1979
Knowlton "Incentive For Excellence" Award, Internal Medicine Program, Washington University School of Medicine, 1986
Clinician-Scientist Award, American Heart Association, 1988-1993
Established Investigator Award, American Heart Association, 1993-1998
Member, American Society of Clinical Investigation (Elected May 1995)
Elected to Board of Directors, Society for Cardiovascular Magnetic Resonance, 2000-2004
Elected Councilor to Society of Molecular Imaging (2004-2007)
Fellow of the American College of Cardiology
Fellow of the American Heart Association
2006 Reneman Laureate, University of Maastricht and Cardiovascular Research, Institute of Maastricht

Selected Publications:
Lanza GM, Winter PM, Caruthers SD, Hughes MS, Cyrus T, Marsh JN, Neubauer AM, Partlow KC, Wickline SA: Nanomedicine opportunities for cardiovascular disease with perfluorocarbon nanoparticles. Nanomedicine 2006; 1: 321-329.

Caruthers SD, Wickline SA, Lanza GM: Nanotechnological applications in medicine. Curr Opin Biotechnol 2007; 18: 26-30.

Neubauer AM, Caruthers SD, Hockett FD, Cyrus T, Robertson JD, Allen JS, Williams TD, Fuhrhop RW, Lanza GM, Wickline SA: Fluorine cardiovascular magnetic resonance angiography in vivo at 1.5 T with perfluorocarbon nanoparticle contrast agents. J Cardiovasc Magn Reson 2007; 9: 565-573.

Winter PM, Cai K, Caruthers SD, Wickline SA, Lanza GM: Emerging nanomedcine opportunities with perfluorocarbon nanoparticles. Expert Rev Med Devices 2007; 4: 137-145.

Hu G, Lijowski M, Zhang H, Partlow KC, Caruthers SD, Kiefer G, Gulyas G, Athey P, Scott MJ, Wickline SA, Lanza GM: Imaging of Vx-2 rabbit tumors with alpha(nu)beta(3)-integrin targeted 111In nanoparticles. Int J Cancer 2007; 120: 1951-1957.

Wickline SA, Neubauer AM, Winter PM, Caruthers SD, Lanza GM: Molecular imaging and therapy of atherosclerosis with targeted nanoparticles. J Magn Reson Imaging 2007; 25: 667-680.

Partlow KC, Chen J, Brant JA, Neubauer AM, Meyerrose TE, Creer MH, Nolta JA, Caruthers SD, Lanza GM, Wickline SA: 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J 2007; 21: 1647-1654.

Marsh JN, Partlow KC, Abendschein DR, Scott MJ, Lanza GM, Wickline SA: Molecularimaging with targeted perfluorocarbon nanoparticles: Quantification of the concentration dependence of contrast enhancement for binding to sparse cellular epitopes. Ultrasound Med Biol 2007; 33: 950-958.

Hughes MS, McCarthy JE, Marsh JN, Arbeit JM, Neumann RG, Fuhrhop RW, Wallace KD, Znidersic DR, Maurizi BN, Baldwin SL, Lanza GM, Wickline SA: Properties of an Entropy-based Signal Receiver with an Application to Ultrasonic Molecular Imaging. J Acous Soc Am 2007; 121: 3542-3557.

Hughes MS, Marsh JN, Wallace KD, Donahue TA, Connolly AM, Lanza GM, Wickline SA: Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with Duchenne muscular dystrophy using an entropy-based signal receiver. Ultrasound Med Biol 2007; 33: 1236-1243.

Marsh JN, Senpan A, Hu G, Scott MJ, Gaffney PJ, Wickline SA, Lanza GM: Fibrin-targeted perfluorocarbon nanoparticles for targeted thrombolysis. Nanomedicine 2007; 2: 533-543.

Cyrus T, Lanza GM, Wickline SA: Molecular imaging by Cardiovascular MR. JCMR 2007; 9: 1-17 (In press).

Ripplinger CM, Li W, Hadley J, Chen J, Rothenberg F, Lombardi R, Wickline SA, Marian AJ, Efimov IR: Enhanced transmural fiber rotation and Cx43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res 2007 (In press)

Tran TD, Caruthers SD, Hughes M, Cyrus T, Winter PM, Morawski AN, Wickline SA, Lanza GM: Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics. Int J Nanomedicine (In press)

Wallace KD, Marsh JN, Baldwin SL, Connolly AM, Keeling R, Lanza GM, Wickline SA, Hughes MS: Sensitive Ultrasonic Delineation of Steroid Treatment in Living Dystrophic Mice with Energy-based and Entropy-based Radio Frequency Signal Processing. IEEE Trans Ultrson Ferroelect Freq Control (In press)


· About the Division · Clinical Programs · Research Activities · Educational Programs · Centers of Excellence · Faculty Faculty Login · Links · Contact Us · Donors	Samuel A. Wickline, M.D. Professor of Medicine, Physics, Biomedical Engineering, Cell Biology and Physiology; Director, Washington University Consortium for Translational Research in Advanced Imaging and Nanomedicine (C-TRAIN); Director, Siteman Center For Cancer Nanotechnology Excellence; Executive Faculty, Institute of Biological and Medical Engineering; Co-Director of Cardiovascular Engineering Graduate Training Program, Biomedical Engineering Department, Washington University School of Medicine, St. Louis, MO Contact Information: Office: 4320 Forest Park; St. Louis, MO 63108 Telephone: 314-454-8635 Email: saw@wuphys.wustl.edu Website: http://ctrain.wustl.edu/ Education and Training: Undergraduate: Pomona College; Claremont, California (1970-74) BA: Philosophy Graduate: University of Hawaii School of Medicine; Honolulu, Hawaii (1976-1980) Academic Positions/Employment: 1974-1976: Research Associate, Cardiovascular Research Laboratory, Queens Hospital and John A. Burns School of Medicine; Honolulu, Hawaii 1980-83: Internship and Residency in Internal Medicine: Barnes Hospital; Washington University School of Medicine; St. Louis, MO 1983-87: Clinical and Research Fellowships in Cardiology: Washington University School of Medicine; Barnes Hospital; St. Louis, MO (Research Fellow 1983-85) 1987: Assistant Professor of Medicine, Washington University School of Medicine, Barnes Hospital; St. Louis, MO 1988: Clinician-Scientist of the American Heart Association 1990: Assistant Professor of Physics, Washington University, Department of Physics; St. Louis, MO 1992: Attending Cardiologist and Director of Echocardiography, The Jewish Hospital at Washington University; St. Louis, MO 1993: Established Investigator of the American Heart Association 1993: Associate Professor of Medicine, Washington University School of Medicine 1993-97: Chief of Cardiology, Jewish Hospital, Washington University School of Medicine 1994: Associate Professor of Physics, Washington University , Department of Physics; St. Louis, MO 1996: Co-Director of Cardiovascular Division, Washington University School of Medicine and Barnes-Jewish Hospital 1996: Co-Director of Washington University Cardiovascular Engineering Program and Member of Executive Council, Institute of Biological and Medical Engineering, Washington University , School of Engineering and Applied Sciences 1997: Professor of Medicine, Washington University School of Medicine 1997: Professor of Physics and of Biomedical Engineering, Washington University School of Medicine 2003: Professor of Cell Biology and Physiology, Division of Biology and Biomedical Sciences, Washington University School of Medicine Honors and Awards: B.A. degree: Cum Laude; Pomona College Lange Award for Outstanding Student sophomore, junior, and senior years; John A. Burns School of Medicine; Honolulu, Hawaii First place awardee: University of Hawaii Biomedical Science Symposium (1977) for presentation of "Vectorcardiographic Infarct Sizing in Baboons" Alpha Omega Alpha, 1979 Knowlton "Incentive For Excellence" Award, Internal Medicine Program, Washington University School of Medicine, 1986 Clinician-Scientist Award, American Heart Association, 1988-1993 Established Investigator Award, American Heart Association, 1993-1998 Member, American Society of Clinical Investigation (Elected May 1995) Elected to Board of Directors, Society for Cardiovascular Magnetic Resonance, 2000-2004 Elected Councilor to Society of Molecular Imaging (2004-2007) Fellow of the American College of Cardiology Fellow of the American Heart Association 2006 Reneman Laureate, University of Maastricht and Cardiovascular Research, Institute of Maastricht Selected Publications: Lanza GM, Winter PM, Caruthers SD, Hughes MS, Cyrus T, Marsh JN, Neubauer AM, Partlow KC, Wickline SA: Nanomedicine opportunities for cardiovascular disease with perfluorocarbon nanoparticles. Nanomedicine 2006; 1: 321-329. Caruthers SD, Wickline SA, Lanza GM: Nanotechnological applications in medicine. Curr Opin Biotechnol 2007; 18: 26-30. Neubauer AM, Caruthers SD, Hockett FD, Cyrus T, Robertson JD, Allen JS, Williams TD, Fuhrhop RW, Lanza GM, Wickline SA: Fluorine cardiovascular magnetic resonance angiography in vivo at 1.5 T with perfluorocarbon nanoparticle contrast agents. J Cardiovasc Magn Reson 2007; 9: 565-573. Winter PM, Cai K, Caruthers SD, Wickline SA, Lanza GM: Emerging nanomedcine opportunities with perfluorocarbon nanoparticles. Expert Rev Med Devices 2007; 4: 137-145. Hu G, Lijowski M, Zhang H, Partlow KC, Caruthers SD, Kiefer G, Gulyas G, Athey P, Scott MJ, Wickline SA, Lanza GM: Imaging of Vx-2 rabbit tumors with alpha(nu)beta(3)-integrin targeted 111In nanoparticles. Int J Cancer 2007; 120: 1951-1957. Wickline SA, Neubauer AM, Winter PM, Caruthers SD, Lanza GM: Molecular imaging and therapy of atherosclerosis with targeted nanoparticles. J Magn Reson Imaging 2007; 25: 667-680. Partlow KC, Chen J, Brant JA, Neubauer AM, Meyerrose TE, Creer MH, Nolta JA, Caruthers SD, Lanza GM, Wickline SA: 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons. FASEB J 2007; 21: 1647-1654. Marsh JN, Partlow KC, Abendschein DR, Scott MJ, Lanza GM, Wickline SA: Molecularimaging with targeted perfluorocarbon nanoparticles: Quantification of the concentration dependence of contrast enhancement for binding to sparse cellular epitopes. Ultrasound Med Biol 2007; 33: 950-958. Hughes MS, McCarthy JE, Marsh JN, Arbeit JM, Neumann RG, Fuhrhop RW, Wallace KD, Znidersic DR, Maurizi BN, Baldwin SL, Lanza GM, Wickline SA: Properties of an Entropy-based Signal Receiver with an Application to Ultrasonic Molecular Imaging. J Acous Soc Am 2007; 121: 3542-3557. Hughes MS, Marsh JN, Wallace KD, Donahue TA, Connolly AM, Lanza GM, Wickline SA: Sensitive ultrasonic detection of dystrophic skeletal muscle in patients with Duchenne muscular dystrophy using an entropy-based signal receiver. Ultrasound Med Biol 2007; 33: 1236-1243. Marsh JN, Senpan A, Hu G, Scott MJ, Gaffney PJ, Wickline SA, Lanza GM: Fibrin-targeted perfluorocarbon nanoparticles for targeted thrombolysis. Nanomedicine 2007; 2: 533-543. Cyrus T, Lanza GM, Wickline SA: Molecular imaging by Cardiovascular MR. JCMR 2007; 9: 1-17 (In press). Ripplinger CM, Li W, Hadley J, Chen J, Rothenberg F, Lombardi R, Wickline SA, Marian AJ, Efimov IR: Enhanced transmural fiber rotation and Cx43 heterogeneity are associated with an increased upper limit of vulnerability in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res 2007 (In press) Tran TD, Caruthers SD, Hughes M, Cyrus T, Winter PM, Morawski AN, Wickline SA, Lanza GM: Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics. Int J Nanomedicine (In press) Wallace KD, Marsh JN, Baldwin SL, Connolly AM, Keeling R, Lanza GM, Wickline SA, Hughes MS: Sensitive Ultrasonic Delineation of Steroid Treatment in Living Dystrophic Mice with Energy-based and Entropy-based Radio Frequency Signal Processing. IEEE Trans Ultrson Ferroelect Freq Control (In press)